Reproducible lung protective effects of a TGFβR1/ALK5 inhibitor in a bleomycin‐induced and spirometr...
Reproducible lung protective effects of a TGFβR1/ALK5 inhibitor in a bleomycin‐induced and spirometry‐confirmed model of IPF in male mice
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Author / Creator
Petersen, Asbjørn Graver , Korntner, Stefanie H. , Bousamaki, Jamal , Oró, Denise , Arraut, Alba Manresa , Pors, Susanne E. , Salinas, Casper Gravesen , Andersen, Maja Worm , Madsen, Martin Rønn , Nie, Yaohui , Butts, Jordan , Roqueta‐Rivera, Manuel , Simonsen, Ulf , Hansen, Henrik H. and Feigh, Michael
Publisher
United States: John Wiley & Sons, Inc
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Language
English
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Publisher
United States: John Wiley & Sons, Inc
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This study comprehensively validated the bleomycin (BLEO) induced mouse model of IPF for utility in preclinical drug discovery. To this end, the model was rigorously evaluated for reproducible phenotype and TGFβ‐directed treatment outcomes. Lung disease was profiled longitudinally in male C57BL6/JRJ mice receiving a single intratracheal instillatio...
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Full title
Reproducible lung protective effects of a TGFβR1/ALK5 inhibitor in a bleomycin‐induced and spirometry‐confirmed model of IPF in male mice
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TN_cdi_doaj_primary_oai_doaj_org_article_cb84d450302846dba69d6266991df0ae
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cb84d450302846dba69d6266991df0ae
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ISSN
2051-817X
E-ISSN
2051-817X
DOI
10.14814/phy2.70077
