Serotonin-prefrontal cortical circuitry in anxiety and depression phenotypes: pivotal role of pre- a...
Serotonin-prefrontal cortical circuitry in anxiety and depression phenotypes: pivotal role of pre- and post-synaptic 5-HT1A receptor expression
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Switzerland: Frontiers Research Foundation
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Language
English
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Switzerland: Frontiers Research Foundation
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Decreased serotonergic activity has been implicated in anxiety and major depression, and antidepressants directly or indirectly increase the long-term activity of the serotonin system. A key component of serotonin circuitry is the 5-HT1A autoreceptor, which functions as the major somatodendritic autoreceptor to negatively regulate the "gain" of the...
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Full title
Serotonin-prefrontal cortical circuitry in anxiety and depression phenotypes: pivotal role of pre- and post-synaptic 5-HT1A receptor expression
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TN_cdi_doaj_primary_oai_doaj_org_article_cbaf4d9170c24ff18e8ce89e064a28c0
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cbaf4d9170c24ff18e8ce89e064a28c0
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ISSN
1662-5153
E-ISSN
1662-5153
DOI
10.3389/fnbeh.2014.00199
