Current gene panels account for nearly all homologous recombination repair-associated multiple-case...
Current gene panels account for nearly all homologous recombination repair-associated multiple-case breast cancer families
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Author / Creator
Matis, Thibaut S. , Zayed, Nadia , Labraki, Bouchra , de Ladurantaye, Manon , Matis, Théophane A. , Camacho Valenzuela, José , Hamel, Nancy , Atayan, Adrienne , Rivera, Barbara , Tabach, Yuval , Tonin, Patricia N. , Orthwein, Alexandre , Mes-Masson, Anne-Marie , El Haffaf, Zaki , Foulkes, William D. and Polak, Paz
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
It was hypothesized that variants in underexplored homologous recombination repair (HR) genes could explain unsolved multiple-case breast cancer (BC) families. We investigated HR deficiency (HRD)-associated mutational signatures and second hits in tumor DNA from familial BC cases. No candidates genes were associated with HRD in 38 probands previous...
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Full title
Current gene panels account for nearly all homologous recombination repair-associated multiple-case breast cancer families
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TN_cdi_doaj_primary_oai_doaj_org_article_cbb6acef8a0543f6b4e46805a7d21ec0
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cbb6acef8a0543f6b4e46805a7d21ec0
Other Identifiers
ISSN
2374-4677
E-ISSN
2374-4677
DOI
10.1038/s41523-021-00315-8
