CD4+ T cells are activated in regional lymph nodes and migrate to skin to initiate lymphedema
CD4+ T cells are activated in regional lymph nodes and migrate to skin to initiate lymphedema
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
T cell-mediated responses have been implicated in the development of fibrosis, impaired lymphangiogenesis, and lymphatic dysfunction in secondary lymphedema. Here we show that CD4
+
T cells are necessary for lymphedema pathogenesis by utilizing adoptive transfer techniques in CD4 knockout mice that have undergone tail skin and lymphatic excis...
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Full title
CD4+ T cells are activated in regional lymph nodes and migrate to skin to initiate lymphedema
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TN_cdi_doaj_primary_oai_doaj_org_article_cbbc4761ee674a4bad5f425e2a34fa9d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cbbc4761ee674a4bad5f425e2a34fa9d
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-04418-y
