Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms under...
Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response
About this item
Full title
Author / Creator
Haberman, Yael , Karns, Rebekah , Dexheimer, Phillip J. , Schirmer, Melanie , Somekh, Judith , Jurickova, Ingrid , Braun, Tzipi , Novak, Elizabeth , Bauman, Laura , Collins, Margaret H. , Mo, Angela , Rosen, Michael J. , Bonkowski, Erin , Gotman, Nathan , Marquis, Alison , Nistel, Mason , Rufo, Paul A. , Baker, Susan S. , Sauer, Cary G. , Markowitz, James , Pfefferkorn, Marian D. , Rosh, Joel R. , Boyle, Brendan M. , Mack, David R. , Baldassano, Robert N. , Shah, Sapana , Leleiko, Neal S. , Heyman, Melvin B. , Grifiths, Anne M. , Patel, Ashish S. , Noe, Joshua D. , Aronow, Bruce J. , Kugathasan, Subra , Walters, Thomas D. , Gibson, Greg , Thomas, Sonia Davis , Mollen, Kevin , Shen-Orr, Shai , Huttenhower, Curtis , Xavier, Ramnik J. , Hyams, Jeffrey S. and Denson, Lee A.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Molecular mechanisms driving disease course and response to therapy in ulcerative colitis (UC) are not well understood. Here, we use RNAseq to define pre-treatment rectal gene expression, and fecal microbiota profiles, in 206 pediatric UC patients receiving standardised therapy. We validate our key findings in adult and paediatric UC cohorts of 408...
Alternative Titles
Full title
Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response
Authors, Artists and Contributors
Author / Creator
Karns, Rebekah
Dexheimer, Phillip J.
Schirmer, Melanie
Somekh, Judith
Jurickova, Ingrid
Braun, Tzipi
Novak, Elizabeth
Bauman, Laura
Collins, Margaret H.
Mo, Angela
Rosen, Michael J.
Bonkowski, Erin
Gotman, Nathan
Marquis, Alison
Nistel, Mason
Rufo, Paul A.
Baker, Susan S.
Sauer, Cary G.
Markowitz, James
Pfefferkorn, Marian D.
Rosh, Joel R.
Boyle, Brendan M.
Mack, David R.
Baldassano, Robert N.
Shah, Sapana
Leleiko, Neal S.
Heyman, Melvin B.
Grifiths, Anne M.
Patel, Ashish S.
Noe, Joshua D.
Aronow, Bruce J.
Kugathasan, Subra
Walters, Thomas D.
Gibson, Greg
Thomas, Sonia Davis
Mollen, Kevin
Shen-Orr, Shai
Huttenhower, Curtis
Xavier, Ramnik J.
Hyams, Jeffrey S.
Denson, Lee A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_cbe3d637f8854aa08026fcc4f3d0a9e7
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cbe3d637f8854aa08026fcc4f3d0a9e7
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-07841-3
