WIP1 Promotes Homologous Recombination and Modulates Sensitivity to PARP Inhibitors
WIP1 Promotes Homologous Recombination and Modulates Sensitivity to PARP Inhibitors
About this item
Full title
Author / Creator
Publisher
Switzerland: MDPI AG
Journal title
Language
English
Formats
Publication information
Publisher
Switzerland: MDPI AG
Subjects
More information
Scope and Contents
Contents
Genotoxic stress triggers a combined action of DNA repair and cell cycle checkpoint pathways. Protein phosphatase 2C delta (referred to as WIP1) is involved in timely inactivation of DNA damage response by suppressing function of p53 and other targets at chromatin. Here we show that WIP1 promotes DNA repair through homologous recombination. Loss or...
Alternative Titles
Full title
WIP1 Promotes Homologous Recombination and Modulates Sensitivity to PARP Inhibitors
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_cc054a673d1f4711b7a91afec9ded164
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cc054a673d1f4711b7a91afec9ded164
Other Identifiers
ISSN
2073-4409
E-ISSN
2073-4409
DOI
10.3390/cells8101258
