Loss of NARS1 impairs progenitor proliferation in cortical brain organoids and leads to microcephaly
Loss of NARS1 impairs progenitor proliferation in cortical brain organoids and leads to microcephaly
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Asparaginyl-tRNA synthetase1 (NARS1) is a member of the ubiquitously expressed cytoplasmic Class IIa family of tRNA synthetases required for protein translation. Here, we identify biallelic missense and frameshift mutations in
NARS1
in seven patients from three unrelated families with microcephaly and neurodevelopmental delay. Patient cells s...
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Full title
Loss of NARS1 impairs progenitor proliferation in cortical brain organoids and leads to microcephaly
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TN_cdi_doaj_primary_oai_doaj_org_article_cc10dd5665ed408989d1b2eddc9acfe5
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cc10dd5665ed408989d1b2eddc9acfe5
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-17454-4
