Bivalent promoter hypermethylation in cancer is linked to the H327me3/H3K4me3 ratio in embryonic ste...
Bivalent promoter hypermethylation in cancer is linked to the H327me3/H3K4me3 ratio in embryonic stem cells
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England: BioMed Central Ltd
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English
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England: BioMed Central Ltd
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Thousands of mammalian promoters are defined by co-enrichment of the histone tail modifications H3K27me3 (repressive) and H3K4me3 (activating) and are thus termed bivalent. It was previously observed that bivalent genes in human ES cells (hESC) are frequent targets for hypermethylation in human cancers, and depletion of DNA methylation in mouse emb...
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Bivalent promoter hypermethylation in cancer is linked to the H327me3/H3K4me3 ratio in embryonic stem cells
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TN_cdi_doaj_primary_oai_doaj_org_article_cc3fa85d4d5d449588d39054315791cf
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cc3fa85d4d5d449588d39054315791cf
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ISSN
1741-7007
E-ISSN
1741-7007
DOI
10.1186/s12915-020-0752-3
