Structures of the wild-type MexAB–OprM tripartite pump reveal its complex formation and drug efflux...
Structures of the wild-type MexAB–OprM tripartite pump reveal its complex formation and drug efflux mechanism
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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In
Pseudomonas aeruginosa
, MexAB–OprM plays a central role in multidrug resistance by ejecting various drug compounds, which is one of the causes of serious nosocomial infections. Although the structures of the components of MexAB–OprM have been solved individually by X-ray crystallography, no structural information for fully assembled pumps...
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Structures of the wild-type MexAB–OprM tripartite pump reveal its complex formation and drug efflux mechanism
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TN_cdi_doaj_primary_oai_doaj_org_article_cc7f1952c6e7489598ccf9dab7aef02c
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cc7f1952c6e7489598ccf9dab7aef02c
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-09463-9
