Polycomb complexes associate with enhancers and promote oncogenic transcriptional programs in cancer...
Polycomb complexes associate with enhancers and promote oncogenic transcriptional programs in cancer through multiple mechanisms
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Polycomb repressive complex 1 (PRC1) plays essential roles in cell fate decisions and development. However, its role in cancer is less well understood. Here, we show that
RNF2
, encoding RING1B, and canonical PRC1 (cPRC1) genes are overexpressed in breast cancer. We find that cPRC1 complexes functionally associate with ERα and its pioneer fac...
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Full title
Polycomb complexes associate with enhancers and promote oncogenic transcriptional programs in cancer through multiple mechanisms
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TN_cdi_doaj_primary_oai_doaj_org_article_cc957fd0d811463b9e87699141c6c633
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cc957fd0d811463b9e87699141c6c633
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-05728-x
