PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma
PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Pediatric high-grade gliomas are among the deadliest of childhood cancers due to limited knowledge of early driving events in their gliomagenesis and the lack of effective therapies available. In this study, we investigate the oncogenic role of PPM1D, a protein phosphatase often found truncated in pediatric gliomas such as DIPG, and uncover a synth...
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PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma
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TN_cdi_doaj_primary_oai_doaj_org_article_cc9d2729a55c414fbabbdf50c1cccd2e
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cc9d2729a55c414fbabbdf50c1cccd2e
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-11732-6
