PKD1 mutation perturbs morphogenesis in tubular epithelial organoids derived from human pluripotent...
PKD1 mutation perturbs morphogenesis in tubular epithelial organoids derived from human pluripotent stem cells
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Autosomal dominant polycystic kidney disease (ADPKD) is the most common renal genetic disease, with most patients carrying mutations in
PKD1
. The main feature is the formation of bilateral renal cysts, leading to end stage renal failure in a significant proportion of those affected. Despite recent advances made in understanding ADPKD, there...
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Full title
PKD1 mutation perturbs morphogenesis in tubular epithelial organoids derived from human pluripotent stem cells
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TN_cdi_doaj_primary_oai_doaj_org_article_cce63f55680a422093d5b6e2ee7601ed
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cce63f55680a422093d5b6e2ee7601ed
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-025-94855-9
