Gliadin-dependent UPR induction directly triggers the expression of TG2 and pro-inflammatory cytokin...
Gliadin-dependent UPR induction directly triggers the expression of TG2 and pro-inflammatory cytokines, dysregulates intestinal permeability, and reduces CFTR expression in intestinal epithelial cells of celiac disease patients
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England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Celiac disease (CD) is an autoimmune disorder that primarily affects the gut of genetically predisposed individuals and is triggered by gliadin peptides (PT) produced by the digestion of gluten. Although inappropriate activation of the immune system is thought to be the main trigger of CD, the interaction between PT and intestinal epithelial cells...
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Full title
Gliadin-dependent UPR induction directly triggers the expression of TG2 and pro-inflammatory cytokines, dysregulates intestinal permeability, and reduces CFTR expression in intestinal epithelial cells of celiac disease patients
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TN_cdi_doaj_primary_oai_doaj_org_article_cd7cc64c63f14396902e95bae64b48e3
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cd7cc64c63f14396902e95bae64b48e3
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ISSN
1745-6150
E-ISSN
1745-6150
DOI
10.1186/s13062-025-00644-9
