USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic targ...
USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer
About this item
Full title
Author / Creator
Nelson, Jessica K. , Thin, May Zaw , Evan, Theodore , Howell, Steven , Wu, Mary , Almeida, Bruna , Legrave, Nathalie , Koenis, Duco S. , Koifman, Gabriela , Sugimoto, Yoichiro , Llorian Sopena, Miriam , MacRae, James , Nye, Emma , Howell, Michael , Snijders, Ambrosius P. , Prachalias, Andreas , Zen, Yoh , Sarker, Debashis and Behrens, Axel
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Deubiquitylating enzymes (DUBs) play an essential role in targeted protein degradation and represent an emerging therapeutic paradigm in cancer. However, their therapeutic potential in pancreatic ductal adenocarcinoma (PDAC) has not been explored. Here, we develop a DUB discovery pipeline, combining activity-based proteomics with a loss-of-function...
Alternative Titles
Full title
USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer
Authors, Artists and Contributors
Author / Creator
Thin, May Zaw
Evan, Theodore
Howell, Steven
Wu, Mary
Almeida, Bruna
Legrave, Nathalie
Koenis, Duco S.
Koifman, Gabriela
Sugimoto, Yoichiro
Llorian Sopena, Miriam
MacRae, James
Nye, Emma
Howell, Michael
Snijders, Ambrosius P.
Prachalias, Andreas
Zen, Yoh
Sarker, Debashis
Behrens, Axel
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_cd8dab384b2a46bf9a9f3d5ce3b2663f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cd8dab384b2a46bf9a9f3d5ce3b2663f
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-29684-9
