Neonatal inflammation increases hippocampal KCC2 expression through methylation-mediated TGF-β1 down...
Neonatal inflammation increases hippocampal KCC2 expression through methylation-mediated TGF-β1 downregulation leading to impaired hippocampal cognitive function and synaptic plasticity in adult mice
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Author / Creator
Rong, Jing , Yang, Yang , Liang, Min , Zhong, Haiquan , Li, Yingchun , Zhu, Yichao , Sha, Sha , Chen, Lei and Zhou, Rong
Publisher
England: BioMed Central
Journal title
Language
English
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Publication information
Publisher
England: BioMed Central
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Scope and Contents
Contents
The mechanisms by which neonatal inflammation leads to cognitive deficits in adulthood remain poorly understood. Inhibitory GABAergic synaptic transmission plays a vital role in controlling learning, memory and synaptic plasticity. Since early-life inflammation has been reported to adversely affect the GABAergic synaptic transmission, the aim of th...
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Full title
Neonatal inflammation increases hippocampal KCC2 expression through methylation-mediated TGF-β1 downregulation leading to impaired hippocampal cognitive function and synaptic plasticity in adult mice
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Author / Creator
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_cdc895b858904e009e2de84585961e0e
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cdc895b858904e009e2de84585961e0e
Other Identifiers
ISSN
1742-2094
E-ISSN
1742-2094
DOI
10.1186/s12974-023-02697-x
