ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PW...
ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism
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Author / Creator
Li, Jie , Galbo, Phillip M. , Gong, Weida , Storey, Aaron J. , Tsai, Yi-Hsuan , Yu, Xufen , Ahn, Jeong Hyun , Guo, Yiran , Mackintosh, Samuel G. , Edmondson, Ricky D. , Byrum, Stephanie D. , Farrar, Jason E. , He, Shenghui , Cai, Ling , Jin, Jian , Tackett, Alan J. , Zheng, Deyou and Wang, Gang Greg
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
Recurring chromosomal translocation t(10;17)(p15;q21) present in a subset of human acute myeloid leukemia (AML) patients creates an aberrant fusion gene termed ZMYND11-MBTD1 (ZM); however, its function remains undetermined. Here, we show that ZM confers primary murine hematopoietic stem/progenitor cells indefinite self-renewal capability ex vivo an...
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Full title
ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism
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TN_cdi_doaj_primary_oai_doaj_org_article_cdcc2ab94850477c835abe99c9bfa857
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cdcc2ab94850477c835abe99c9bfa857
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-21357-3
