m6A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation...
m6A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling
About this item
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Author / Creator
Tang, Bo , Yang, Yihua , Kang, Min , Wang, Yunshan , Wang, Yan , Bi, Yin , He, Songqing and Shimamoto, Fumio
Publisher
London: BioMed Central Ltd
Journal title
Language
English
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Publication information
Publisher
London: BioMed Central Ltd
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Scope and Contents
Contents
Background Pancreatic cancer is one of the most lethal types of cancer with extremely poor diagnosis and prognosis, and chemo-resistance remains a major challenge. The dynamic and reversible N.sup.6-methyladenosine (m.sup.6A) RNA modification has emerged as a new layer of epigenetic gene regulation. Methods qRT-PCR and IHC were applied to examine A...
Alternative Titles
Full title
m6A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling
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Author / Creator
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_cdd039ed818740b4ae51633a01fa87a3
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cdd039ed818740b4ae51633a01fa87a3
Other Identifiers
ISSN
1476-4598
E-ISSN
1476-4598
DOI
10.1186/s12943-019-1128-6
