CAR T cells targeting CD99 as an approach to eradicate T-cell acute lymphoblastic leukemia without n...
CAR T cells targeting CD99 as an approach to eradicate T-cell acute lymphoblastic leukemia without normal blood cells toxicity
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Author / Creator
Shi, Jiangzhou , Zhang, Zijian , Cen, Hong , Wu, Han , Zhang, Shangkun , Liu, Jiaxing , Leng, Yingqi , Ren, Anqi , Liu, Xiyu , Zhang, Zhijie , Tong, Xiqin , Liang, Jinjue , Li, Zhe , Zhou, Fuling , Huang, Liang , Qin, You , Yang, Kunyu , Zhang, Tongcun and Zhu, Haichuan
Publisher
London: BioMed Central Ltd
Journal title
Language
English
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Publication information
Publisher
London: BioMed Central Ltd
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Scope and Contents
Contents
CAR T cell therapy has shown dramatic clinical success in relapsed or refractory B-ALL and other hematological malignancies. However, the loss of specific antigens, cell fratricide, T cell aplasia, and normal T cell separation are challenges in treating T cell leukemia/lymphoma with CAR T therapy. CD99 is a promising antigen to target T-ALL and AML...
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Full title
CAR T cells targeting CD99 as an approach to eradicate T-cell acute lymphoblastic leukemia without normal blood cells toxicity
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_cdd07b8c15f7452a85789dbe956485a0
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cdd07b8c15f7452a85789dbe956485a0
Other Identifiers
ISSN
1756-8722
E-ISSN
1756-8722
DOI
10.1186/s13045-021-01178-z
