Pharmacological inhibition of HDAC6 improves muscle phenotypes in dystrophin-deficient mice by downr...
Pharmacological inhibition of HDAC6 improves muscle phenotypes in dystrophin-deficient mice by downregulating TGF-β via Smad3 acetylation
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The absence of dystrophin in Duchenne muscular dystrophy disrupts the dystrophin-associated glycoprotein complex resulting in skeletal muscle fiber fragility and atrophy, associated with fibrosis as well as microtubule and neuromuscular junction disorganization. The specific, non-conventional cytoplasmic histone deacetylase 6 (HDAC6) was recently s...
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Pharmacological inhibition of HDAC6 improves muscle phenotypes in dystrophin-deficient mice by downregulating TGF-β via Smad3 acetylation
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TN_cdi_doaj_primary_oai_doaj_org_article_cdf9d7e3e2ad4da9b5e4aa9491b771ee
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cdf9d7e3e2ad4da9b5e4aa9491b771ee
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2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-34831-3
