Structural insight into small molecule action on Frizzleds
Structural insight into small molecule action on Frizzleds
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
WNT-Frizzled (FZD) signaling plays a critical role in embryonic development, stem cell regulation and tissue homeostasis. FZDs are linked to severe human pathology and are seen as a promising target for therapy. Despite intense efforts, no small molecule drugs with distinct efficacy have emerged. Here, we identify the Smoothened agonist SAG1.3 as a...
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Structural insight into small molecule action on Frizzleds
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TN_cdi_doaj_primary_oai_doaj_org_article_cdfb04c677084c808ef1126575dae7a6
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cdfb04c677084c808ef1126575dae7a6
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-14149-3
