EPAC1 inhibition protects the heart from doxorubicin-induced toxicity
EPAC1 inhibition protects the heart from doxorubicin-induced toxicity
About this item
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Author / Creator
Mazevet, Marianne , Belhadef, Anissa , Ribeiro, Maxance , Dayde, Delphine , Llach, Anna , Laudette, Marion , Belleville, Tiphaine , Mateo, Philippe , Gressette, Mélanie , Lefebvre, Florence , Chen, Ju , Bachelot-Loza, Christilla , Rucker-Martin, Catherine , Lezoualch, Frank , Crozatier, Bertrand , Benitah, Jean-Pierre , Vozenin, Marie-Catherine , Fischmeister, Rodolphe , Gomez, Ana-Maria , Lemaire, Christophe and Morel, Eric
Publisher
England: eLife Science Publications, Ltd
Journal title
Language
English
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Publication information
Publisher
England: eLife Science Publications, Ltd
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More information
Scope and Contents
Contents
Anthracyclines, such as doxorubicin (Dox), are widely used chemotherapeutic agents for the treatment of solid tumors and hematologic malignancies. However, they frequently induce cardiotoxicity leading to dilated cardiomyopathy and heart failure. This study sought to investigate the role of the exchange protein directly activated by cAMP (EPAC) in...
Alternative Titles
Full title
EPAC1 inhibition protects the heart from doxorubicin-induced toxicity
Authors, Artists and Contributors
Author / Creator
Belhadef, Anissa
Ribeiro, Maxance
Dayde, Delphine
Llach, Anna
Laudette, Marion
Belleville, Tiphaine
Mateo, Philippe
Gressette, Mélanie
Lefebvre, Florence
Chen, Ju
Bachelot-Loza, Christilla
Rucker-Martin, Catherine
Lezoualch, Frank
Crozatier, Bertrand
Benitah, Jean-Pierre
Vozenin, Marie-Catherine
Fischmeister, Rodolphe
Gomez, Ana-Maria
Lemaire, Christophe
Morel, Eric
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_cdffeb33bb6c47cd87e41bc7a93230d4
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cdffeb33bb6c47cd87e41bc7a93230d4
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.83831
