In vivo perturb-seq of cancer and microenvironment cells dissects oncologic drivers and radiotherapy...
In vivo perturb-seq of cancer and microenvironment cells dissects oncologic drivers and radiotherapy responses in glioblastoma
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Author / Creator
Liu, S. John , Zou, Christopher , Pak, Joanna , Morse, Alexandra , Pang, Dillon , Casey-Clyde, Timothy , Borah, Ashir A. , Wu, David , Seo, Kyounghee , O’Loughlin, Thomas , Lim, Daniel A. , Ozawa, Tomoko , Berger, Mitchel S. , Kamber, Roarke A. , Weiss, William A. , Raleigh, David R. and Gilbert, Luke A.
Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Genetic perturbation screens with single-cell readouts have enabled rich phenotyping of gene function and regulatory networks. These approaches have been challenging in vivo, especially in adult disease models such as cancer, which include mixtures of malignant and microenvironment cells. Glioblastoma (GBM) is a fatal cancer, and methods of systema...
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Full title
In vivo perturb-seq of cancer and microenvironment cells dissects oncologic drivers and radiotherapy responses in glioblastoma
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TN_cdi_doaj_primary_oai_doaj_org_article_ce15256d82df4ae7a07d376548cbf5c6
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ce15256d82df4ae7a07d376548cbf5c6
Other Identifiers
ISSN
1474-760X,1474-7596
E-ISSN
1474-760X
DOI
10.1186/s13059-024-03404-6
