Modulation of histone H3K4 dimethylation by spermidine ameliorates motor neuron survival and neuropa...
Modulation of histone H3K4 dimethylation by spermidine ameliorates motor neuron survival and neuropathology in a mouse model of ALS
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England: BioMed Central Ltd
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English
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England: BioMed Central Ltd
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Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive paralysis due to motor neuron degeneration. It has been proposed that epigenetic modification and transcriptional dysregulation may contribute to motor neuron death. In this study, we investigate the basis for therapeutic approaches to target lysi...
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Modulation of histone H3K4 dimethylation by spermidine ameliorates motor neuron survival and neuropathology in a mouse model of ALS
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TN_cdi_doaj_primary_oai_doaj_org_article_ce1f5c250fe848ecbc04308709d14522
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ce1f5c250fe848ecbc04308709d14522
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ISSN
1423-0127,1021-7770
E-ISSN
1423-0127
DOI
10.1186/s12929-022-00890-3
