N6-methyladenosine dynamics in neurodevelopment and aging, and its potential role in Alzheimer’s dis...
N6-methyladenosine dynamics in neurodevelopment and aging, and its potential role in Alzheimer’s disease
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Author / Creator
Shafik, Andrew M. , Zhang, Feiran , Guo, Zhenxing , Dai, Qing , Pajdzik, Kinga , Li, Yangping , Kang, Yunhee , Yao, Bing , Wu, Hao , He, Chuan , Allen, Emily G. , Duan, Ranhui and Jin, Peng
Publisher
England: BioMed Central Ltd
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Language
English
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Publication information
Publisher
England: BioMed Central Ltd
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Contents
N6-methyladenosine (m
A) modification is known to impact many aspects of RNA metabolism, including mRNA stability and translation, and is highly prevalent in the brain.
We show that m
A modification displays temporal and spatial dynamics during neurodevelopment and aging. Genes that are temporally differentially methylated are more prone t...
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Full title
N6-methyladenosine dynamics in neurodevelopment and aging, and its potential role in Alzheimer’s disease
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TN_cdi_doaj_primary_oai_doaj_org_article_cea64a1bde4e4e2a803a490e79c90888
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cea64a1bde4e4e2a803a490e79c90888
Other Identifiers
ISSN
1474-760X,1474-7596
E-ISSN
1474-760X
DOI
10.1186/s13059-020-02249-z
