Rapid and reversible epigenome editing by endogenous chromatin regulators
Rapid and reversible epigenome editing by endogenous chromatin regulators
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Understanding the causal link between epigenetic marks and gene regulation remains a central question in chromatin biology. To edit the epigenome we developed the FIRE-Cas9 system for rapid and reversible recruitment of endogenous chromatin regulators to specific genomic loci. We enhanced the dCas9–MS2 anchor for genome targeting with Fkbp/Frb dime...
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Full title
Rapid and reversible epigenome editing by endogenous chromatin regulators
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TN_cdi_doaj_primary_oai_doaj_org_article_ceb7020dd5784ed49c21a33809ac7893
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ceb7020dd5784ed49c21a33809ac7893
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-00644-y
