The effect of fatty diacid acylation of human PYY3-36 on Y2 receptor potency and half-life in minipi...
The effect of fatty diacid acylation of human PYY3-36 on Y2 receptor potency and half-life in minipigs
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Author / Creator
Østergaard, Søren , Paulsson, Johan F. , Kofoed, Jacob , Zosel, Franziska , Olsen, Jørgen , Jeppesen, Claus Bekker , Spetzler, Jane , Ynddal, Lars , Schleiss, Luise Gram , Christoffersen, Berit Østergaard , Raun, Kirsten , Sensfuss, Ulrich , Nielsen, Flemming Seier , Jørgensen, Rasmus and Wulff, Birgitte S.
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Peptides are notoriously known to display very short
in vivo
half-lives often measured in minutes which in many cases greatly reduces or eliminates sufficient
in vivo
efficacy. To obtain long half-lives allowing for up to once-weekly dosing regimen, fatty acid acylation (lipidation) have been used to non-covalently associate the peptide...
Alternative Titles
Full title
The effect of fatty diacid acylation of human PYY3-36 on Y2 receptor potency and half-life in minipigs
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TN_cdi_doaj_primary_oai_doaj_org_article_cec7ec4e645c44c5a30946919c1e7741
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cec7ec4e645c44c5a30946919c1e7741
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-021-00654-3
