Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer
Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer
About this item
Full title
Author / Creator
Bartolacci, Caterina , Andreani, Cristina , Vale, Gonçalo , Berto, Stefano , Melegari, Margherita , Crouch, Anna Colleen , Baluya, Dodge L. , Kemble, George , Hodges, Kurt , Starrett, Jacqueline , Politi, Katerina , Starnes, Sandra L. , Lorenzini, Daniele , Raso, Maria Gabriela , Solis Soto, Luisa M. , Behrens, Carmen , Kadara, Humam , Gao, Boning , Wistuba, Ignacio I. , Minna, John D. , McDonald, Jeffrey G. and Scaglioni, Pier Paolo
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Mutant
KRAS
(KM), the most common oncogene in lung cancer (LC), regulates fatty acid (FA) metabolism. However, the role of FA in LC tumorigenesis is still not sufficiently characterized. Here, we show that KMLC has a specific lipid profile, with high triacylglycerides and phosphatidylcholines (PC). We demonstrate that FASN, the rate-limiting...
Alternative Titles
Full title
Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer
Authors, Artists and Contributors
Author / Creator
Andreani, Cristina
Vale, Gonçalo
Berto, Stefano
Melegari, Margherita
Crouch, Anna Colleen
Baluya, Dodge L.
Kemble, George
Hodges, Kurt
Starrett, Jacqueline
Politi, Katerina
Starnes, Sandra L.
Lorenzini, Daniele
Raso, Maria Gabriela
Solis Soto, Luisa M.
Behrens, Carmen
Kadara, Humam
Gao, Boning
Wistuba, Ignacio I.
Minna, John D.
McDonald, Jeffrey G.
Scaglioni, Pier Paolo
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_cecb398260bb4e0d93d08e97a822d9aa
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cecb398260bb4e0d93d08e97a822d9aa
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-31963-4
