Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inf...
Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways
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Author / Creator
Kurmasheva, Naziia , Said, Aida , Wong, Boaz , Kinderman, Priscilla , Han, Xiaoying , Rahimic, Anna H. F. , Kress, Alena , Carter-Timofte, Madalina E. , Holm, Emilia , van der Horst, Demi , Kollmann, Christoph F. , Liu, Zhenlong , Wang, Chen , Hoang, Huy-Dung , Kovalenko, Elina , Chrysopoulou, Maria , Twayana, Krishna Sundar , Ottosen, Rasmus N. , Svenningsen, Esben B. , Begnini, Fabio , Kiib, Anders E. , Kromm, Florian E. H. , Weiss, Hauke J. , Di Carlo, Daniele , Muscolini, Michela , Higgins, Maureen , van der Heijden, Mirte , Arulanandam, Rozanne , Bardoul, Angelina , Tong, Tong , Ozsvar, Attila , Hou, Wen-Hsien , Schack, Vivien R. , Holm, Christian K. , Zheng, Yunan , Ruzek, Melanie , Kalucka, Joanna , de la Vega, Laureano , Elgaher, Walid A. M. , Korshoej, Anders R. , Lin, Rongtuan , Hiscott, John , Poulsen, Thomas B. , O’Neill, Luke A. , Roy, Dominic G. , Rinschen, Markus M. , van Montfoort, Nadine , Diallo, Jean-Simon , Farin, Henner F. , Alain, Tommy and Olagnier, David
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
The presence of heterogeneity in responses to oncolytic virotherapy poses a barrier to clinical effectiveness, as resistance to this treatment can occur through the inhibition of viral spread within the tumor, potentially leading to treatment failures. Here we show that 4-octyl itaconate (4-OI), a chemical derivative of the Krebs cycle-derived meta...
Alternative Titles
Full title
Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways
Authors, Artists and Contributors
Author / Creator
Said, Aida
Wong, Boaz
Kinderman, Priscilla
Han, Xiaoying
Rahimic, Anna H. F.
Kress, Alena
Carter-Timofte, Madalina E.
Holm, Emilia
van der Horst, Demi
Kollmann, Christoph F.
Liu, Zhenlong
Wang, Chen
Hoang, Huy-Dung
Kovalenko, Elina
Chrysopoulou, Maria
Twayana, Krishna Sundar
Ottosen, Rasmus N.
Svenningsen, Esben B.
Begnini, Fabio
Kiib, Anders E.
Kromm, Florian E. H.
Weiss, Hauke J.
Di Carlo, Daniele
Muscolini, Michela
Higgins, Maureen
van der Heijden, Mirte
Arulanandam, Rozanne
Bardoul, Angelina
Tong, Tong
Ozsvar, Attila
Hou, Wen-Hsien
Schack, Vivien R.
Holm, Christian K.
Zheng, Yunan
Ruzek, Melanie
Kalucka, Joanna
de la Vega, Laureano
Elgaher, Walid A. M.
Korshoej, Anders R.
Lin, Rongtuan
Hiscott, John
Poulsen, Thomas B.
O’Neill, Luke A.
Roy, Dominic G.
Rinschen, Markus M.
van Montfoort, Nadine
Diallo, Jean-Simon
Farin, Henner F.
Alain, Tommy
Olagnier, David
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_cf343351f5cf4766ad351ee93729ee99
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cf343351f5cf4766ad351ee93729ee99
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-48422-x
