Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of s...
Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of sterol synthesis
About this item
Full title
Author / Creator
Yamada, Naoya , Karasawa, Tadayoshi , Ito, Junya , Yamamuro, Daisuke , Morimoto, Kazushi , Nakamura, Toshitaka , Komada, Takanori , Baatarjav, Chintogtokh , Saimoto, Yuma , Jinnouchi, Yuka , Watanabe, Kazuhisa , Miura, Kouichi , Yahagi, Naoya , Nakagawa, Kiyotaka , Matsumura, Takayoshi , Yamada, Ken-ichi , Ishibashi, Shun , Sata, Naohiro , Conrad, Marcus and Takahashi, Masafumi
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Recent evidence indicates ferroptosis is implicated in the pathophysiology of various liver diseases; however, the organ-specific regulation mechanism is poorly understood. Here, we demonstrate 7-dehydrocholesterol reductase (DHCR7), the terminal enzyme of cholesterol biosynthesis, as a regulator of ferroptosis in hepatocytes. Genetic and pharmacol...
Alternative Titles
Full title
Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of sterol synthesis
Authors, Artists and Contributors
Author / Creator
Karasawa, Tadayoshi
Ito, Junya
Yamamuro, Daisuke
Morimoto, Kazushi
Nakamura, Toshitaka
Komada, Takanori
Baatarjav, Chintogtokh
Saimoto, Yuma
Jinnouchi, Yuka
Watanabe, Kazuhisa
Miura, Kouichi
Yahagi, Naoya
Nakagawa, Kiyotaka
Matsumura, Takayoshi
Yamada, Ken-ichi
Ishibashi, Shun
Sata, Naohiro
Conrad, Marcus
Takahashi, Masafumi
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_cf67912edd5e4955a7683d3553f31fd5
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cf67912edd5e4955a7683d3553f31fd5
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-46386-6
