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Cas9-derived peptides presented by MHC Class II that elicit proliferation of CD4+ T-cells

Cas9-derived peptides presented by MHC Class II that elicit proliferation of CD4+ T-cells

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cfab9360e97b4aa380519906ce6d7273

Cas9-derived peptides presented by MHC Class II that elicit proliferation of CD4+ T-cells

About this item

Full title

Cas9-derived peptides presented by MHC Class II that elicit proliferation of CD4+ T-cells

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2021-08, Vol.12 (1), p.5090-5090, Article 5090

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

CRISPR–Cas9 mediated genome editing offers unprecedented opportunities for treating human diseases. There are several reports that demonstrate pre-existing immune responses to Cas9 which may have implications for clinical development of CRISPR-Cas9 mediated gene therapy. Here we use 209 overlapping peptides that span the entire sequence of Staphylo...

Alternative Titles

Full title

Cas9-derived peptides presented by MHC Class II that elicit proliferation of CD4+ T-cells

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_cfab9360e97b4aa380519906ce6d7273

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cfab9360e97b4aa380519906ce6d7273

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-021-25414-9

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