WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling
WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling
About this item
Full title
Author / Creator
Chen, Huimei , Moreno-Moral, Aida , Pesce, Francesco , Devapragash, Nithya , Mancini, Massimiliano , Heng, Ee Ling , Rotival, Maxime , Srivastava, Prashant K. , Harmston, Nathan , Shkura, Kirill , Rackham, Owen J. L. , Yu, Wei-Ping , Sun, Xi-Ming , Tee, Nicole Gui Zhen , Tan, Elisabeth Li Sa , Barton, Paul J. R. , Felkin, Leanne E. , Lara-Pezzi, Enrique , Angelini, Gianni , Beltrami, Cristina , Pravenec, Michal , Schafer, Sebastian , Bottolo, Leonardo , Hubner, Norbert , Emanueli, Costanza , Cook, Stuart A. and Petretto, Enrico
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Cardiac fibrosis is a final common pathology in inherited and acquired heart diseases that causes cardiac electrical and pump failure. Here, we use systems genetics to identify a pro-fibrotic gene network in the diseased heart and show that this network is regulated by the E3 ubiquitin ligase
WWP2
, specifically by the
WWP2-N
terminal i...
Alternative Titles
Full title
WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling
Authors, Artists and Contributors
Author / Creator
Moreno-Moral, Aida
Pesce, Francesco
Devapragash, Nithya
Mancini, Massimiliano
Heng, Ee Ling
Rotival, Maxime
Srivastava, Prashant K.
Harmston, Nathan
Shkura, Kirill
Rackham, Owen J. L.
Yu, Wei-Ping
Sun, Xi-Ming
Tee, Nicole Gui Zhen
Tan, Elisabeth Li Sa
Barton, Paul J. R.
Felkin, Leanne E.
Lara-Pezzi, Enrique
Angelini, Gianni
Beltrami, Cristina
Pravenec, Michal
Schafer, Sebastian
Bottolo, Leonardo
Hubner, Norbert
Emanueli, Costanza
Cook, Stuart A.
Petretto, Enrico
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_cfb1b8ece2684ea692a537c58f79dad3
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cfb1b8ece2684ea692a537c58f79dad3
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-11551-9
