Ogt-mediated O-GlcNAcylation inhibits astrocytes activation through modulating NF-κB signaling pathw...
Ogt-mediated O-GlcNAcylation inhibits astrocytes activation through modulating NF-κB signaling pathway
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Author / Creator
Dong, Xiaoxue , Shu, Liqi , Zhang, Jinyu , Yang, Xu , Cheng, Xuejun , Zhao, Xingsen , Qu, Wenzheng , Zhu, Qiang , Shou, Yikai , Peng, Guoping , Sun, Binggui , Yi, Wen , Shu, Qiang and Li, Xuekun
Publisher
England: BioMed Central
Journal title
Language
English
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Publication information
Publisher
England: BioMed Central
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Scope and Contents
Contents
Previous studies have shown that Ogt-mediated O-GlcNAcylation is essential for neuronal development and function. However, the function of O-GlcNAc transferase (Ogt) and O-GlcNAcylation in astrocytes remains largely unknown. Here we show that
Ogt
deficiency induces inflammatory activation of astrocytes in vivo and in vitro, and impairs cognit...
Alternative Titles
Full title
Ogt-mediated O-GlcNAcylation inhibits astrocytes activation through modulating NF-κB signaling pathway
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_cff9bbf32161460396f938618c10ac86
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cff9bbf32161460396f938618c10ac86
Other Identifiers
ISSN
1742-2094
E-ISSN
1742-2094
DOI
10.1186/s12974-023-02824-8
