A virus-packageable CRISPR screen identifies host factors mediating interferon inhibition of HIV
A virus-packageable CRISPR screen identifies host factors mediating interferon inhibition of HIV
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England: eLife Sciences Publications Ltd
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Language
English
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Publisher
England: eLife Sciences Publications Ltd
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Interferon (IFN) inhibits HIV replication by inducing antiviral effectors. To comprehensively identify IFN-induced HIV restriction factors, we assembled a CRISPR sgRNA library of Interferon Stimulated Genes (ISGs) into a modified lentiviral vector that allows for packaging of sgRNA-encoding genomes
into budding HIV-1 particles. We observed that...
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Full title
A virus-packageable CRISPR screen identifies host factors mediating interferon inhibition of HIV
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TN_cdi_doaj_primary_oai_doaj_org_article_d00363c9c13a413a99b3da1064c12277
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d00363c9c13a413a99b3da1064c12277
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.39823
