Perturbation of Methionine/S-adenosylmethionine Metabolism as a Novel Vulnerability in MLL Rearrange...
Perturbation of Methionine/S-adenosylmethionine Metabolism as a Novel Vulnerability in MLL Rearranged Leukemia
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Publisher
Switzerland: MDPI AG
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Language
English
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Publisher
Switzerland: MDPI AG
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Contents
Leukemias bearing mixed lineage leukemia (MLL) rearrangement (MLL-R) resulting in expression of oncogenic MLL fusion proteins (MLL-FPs) represent an especially aggressive disease subtype with the worst overall prognoses and chemotherapeutic response. MLL-R leukemias are uniquely dependent on the epigenetic function of the H3K79 methyltransferase DO...
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Full title
Perturbation of Methionine/S-adenosylmethionine Metabolism as a Novel Vulnerability in MLL Rearranged Leukemia
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TN_cdi_doaj_primary_oai_doaj_org_article_d003caf9e64c460c81794223ae17b089
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d003caf9e64c460c81794223ae17b089
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ISSN
2073-4409
E-ISSN
2073-4409
DOI
10.3390/cells8111322
