Astrocytic spermidine insufficiency contributes to enhanced pain sensitivity associated with ApoE4
Astrocytic spermidine insufficiency contributes to enhanced pain sensitivity associated with ApoE4
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Author / Creator
Yu, Kaiming , Zhou, Xiongyao , Li, Baolong , Sun, Jialu , Yang, Tuo , Li, Weizhen , Wang, Ningning , Gu, Xiaosong , Cui, Shusen and Cao, Rangjuan
Publisher
Milan: Springer Milan
Journal title
Language
English
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Publisher
Milan: Springer Milan
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Contents
Neuropathic pain is a chronic condition with limited effective treatments, closely associated with astrocytes and their role in central sensitization. Apolipoprotein E (ApoE), predominantly expressed in astrocytes in central nervous system, exists in three ApoE isoforms (ApoE2, ApoE3, and ApoE4) in humans, with ApoE4 linked to increased susceptibil...
Alternative Titles
Full title
Astrocytic spermidine insufficiency contributes to enhanced pain sensitivity associated with ApoE4
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_d00baf50f2ee48939508833f83d32b95
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d00baf50f2ee48939508833f83d32b95
Other Identifiers
ISSN
1129-2377,1129-2369
E-ISSN
1129-2377
DOI
10.1186/s10194-025-02054-8
