Oncolytic adenovirus programmed by synthetic gene circuit for cancer immunotherapy
Oncolytic adenovirus programmed by synthetic gene circuit for cancer immunotherapy
About this item
Full title
Author / Creator
Huang, Huiya , Liu, Yiqi , Liao, Weixi , Cao, Yubing , Liu, Qiang , Guo, Yakun , Lu, Yinying and Xie, Zhen
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Improving efficacy of oncolytic virotherapy remains challenging due to difficulty increasing specificity and immune responses against cancer and limited understanding of its population dynamics. Here, we construct programmable and modular synthetic gene circuits to control adenoviral replication and release of immune effectors selectively in hepato...
Alternative Titles
Full title
Oncolytic adenovirus programmed by synthetic gene circuit for cancer immunotherapy
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_d02993ca48bb47c3813974088403a7cc
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d02993ca48bb47c3813974088403a7cc
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-12794-2
