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Oncolytic adenovirus programmed by synthetic gene circuit for cancer immunotherapy

Oncolytic adenovirus programmed by synthetic gene circuit for cancer immunotherapy

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d02993ca48bb47c3813974088403a7cc

Oncolytic adenovirus programmed by synthetic gene circuit for cancer immunotherapy

About this item

Full title

Oncolytic adenovirus programmed by synthetic gene circuit for cancer immunotherapy

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2019-10, Vol.10 (1), p.4801-15, Article 4801

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Improving efficacy of oncolytic virotherapy remains challenging due to difficulty increasing specificity and immune responses against cancer and limited understanding of its population dynamics. Here, we construct programmable and modular synthetic gene circuits to control adenoviral replication and release of immune effectors selectively in hepato...

Alternative Titles

Full title

Oncolytic adenovirus programmed by synthetic gene circuit for cancer immunotherapy

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_d02993ca48bb47c3813974088403a7cc

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d02993ca48bb47c3813974088403a7cc

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-019-12794-2

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