Intrathecal IgG and IgM synthesis correlates with neurodegeneration markers and corresponds to menin...
Intrathecal IgG and IgM synthesis correlates with neurodegeneration markers and corresponds to meningeal B cell presence in MS
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Author / Creator
Rodriguez-Mogeda, Carla , van Gool, Melissa MJ , van der Mast, Richard , Nijland, Rutger , Keasberry, Zoë , van de Bovekamp, Lisanne , van Delft, Myrthe AM , Picon, Carmen , Reynolds, Richard , Killestein, Joep , Teunissen, Charlotte E , de Vries, Helga E , van Egmond, Marjolein and Witte, Maarten E
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Intrathecal synthesis of immunoglobulins (Igs) is a key hallmark of multiple sclerosis (MS). B cells are known to accumulate in the leptomeninges of MS patients and associate with pathology in the underlying cortex and a more severe disease course. However, the role of locally produced antibodies in MS brain pathology is poorly understood. Here, we...
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Full title
Intrathecal IgG and IgM synthesis correlates with neurodegeneration markers and corresponds to meningeal B cell presence in MS
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_d0785083e3a8472d80607cfbb25ef070
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d0785083e3a8472d80607cfbb25ef070
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-024-76969-8
