EML4-ALK-mediated activation of the JAK2-STAT pathway is critical for non-small cell lung cancer tra...
EML4-ALK-mediated activation of the JAK2-STAT pathway is critical for non-small cell lung cancer transformation
About this item
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Author / Creator
Li, Ying , Li, Yongwen , Zhang, Hongbing , Shi, Ruifeng , Zhang, Zihe , Liu, Hongyu and Chen, Jun
Publisher
London: BioMed Central Ltd
Journal title
Language
English
Formats
Publication information
Publisher
London: BioMed Central Ltd
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Scope and Contents
Contents
Background The echinoderm microtubule-associated protein-like-4 anaplastic lymphoma kinase (EML4-ALK) fusion gene was identified in a subset of non-small cell lung cancer (NSCLC) patients. They responded positively to ALK inhibitors. This study aimed to characterize the mechanisms triggered by EML4-ALK to induce NSCLC transformation. Methods HEK293...
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Full title
EML4-ALK-mediated activation of the JAK2-STAT pathway is critical for non-small cell lung cancer transformation
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Author / Creator
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_d0966cd665c042128955928916e54faa
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d0966cd665c042128955928916e54faa
Other Identifiers
ISSN
1471-2466
E-ISSN
1471-2466
DOI
10.1186/s12890-021-01553-z
