The GLP-1R agonist semaglutide reshapes pancreatic cancer associated fibroblasts reducing collagen p...
The GLP-1R agonist semaglutide reshapes pancreatic cancer associated fibroblasts reducing collagen proline hydroxylation and favoring T lymphocyte infiltration
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Author / Creator
Cencioni, Chiara , Malatesta, Silvia , Vigiano Benedetti, Virginia , Licursi, Valerio , Perfetto, Livia , Conte, Federica , Ranieri, Danilo , Bartolazzi, Armando , Kunkl, Martina , Tuosto, Loretta , Larghi, Alberto , Piro, Geny , Agostini, Antonio , Tortora, Giampaolo , Corbo, Vincenzo , Carbone, Carmine and Spallotta, Francesco
Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Metabolic syndrome represents a pancreatic ductal adenocarcinoma (PDAC) risk factor. Metabolic alterations favor PDAC onset, which occurs early upon dysmetabolism. Pancreatic neoplastic lesions evolve within a dense desmoplastic stroma, consisting in abundant extracellular matrix settled by cancer associated fibroblasts (CAFs). Hereby, dysmetabolis...
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Full title
The GLP-1R agonist semaglutide reshapes pancreatic cancer associated fibroblasts reducing collagen proline hydroxylation and favoring T lymphocyte infiltration
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Author / Creator
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_d098e291964841d2a7d39364dab547be
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d098e291964841d2a7d39364dab547be
Other Identifiers
ISSN
1756-9966,0392-9078
E-ISSN
1756-9966
DOI
10.1186/s13046-024-03263-w
