Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregatio...
Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation
About this item
Full title
Author / Creator
Kelmer Sacramento, Erika , Kirkpatrick, Joanna M , Mazzetto, Mariateresa , Baumgart, Mario , Bartolome, Aleksandar , Di Sanzo, Simone , Caterino, Cinzia , Sanguanini, Michele , Papaevgeniou, Nikoletta , Lefaki, Maria , Childs, Dorothee , Bagnoli, Sara , Terzibasi Tozzini, Eva , Di Fraia, Domenico , Romanov, Natalie , Sudmant, Peter H , Huber, Wolfgang , Chondrogianni, Niki , Vendruscolo, Michele , Cellerino, Alessandro and Ori, Alessandro
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
A progressive loss of protein homeostasis is characteristic of aging and a driver of neurodegeneration. To investigate this process quantitatively, we characterized proteome dynamics during brain aging in the short‐lived vertebrate
Nothobranchius furzeri
combining transcriptomics and proteomics. We detected a progressive reduction in the corr...
Alternative Titles
Full title
Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation
Authors, Artists and Contributors
Author / Creator
Kirkpatrick, Joanna M
Mazzetto, Mariateresa
Baumgart, Mario
Bartolome, Aleksandar
Di Sanzo, Simone
Caterino, Cinzia
Sanguanini, Michele
Papaevgeniou, Nikoletta
Lefaki, Maria
Childs, Dorothee
Bagnoli, Sara
Terzibasi Tozzini, Eva
Di Fraia, Domenico
Romanov, Natalie
Sudmant, Peter H
Huber, Wolfgang
Chondrogianni, Niki
Vendruscolo, Michele
Cellerino, Alessandro
Ori, Alessandro
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_d0fdedc91a124678a4c4681ccc1e444c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d0fdedc91a124678a4c4681ccc1e444c
Other Identifiers
ISSN
1744-4292
E-ISSN
1744-4292
DOI
10.15252/msb.20209596
