CHIT1 at diagnosis predicts faster disability progression and reflects early microglial activation i...
CHIT1 at diagnosis predicts faster disability progression and reflects early microglial activation in multiple sclerosis
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Multiple sclerosis (MS) is characterized by heterogeneity in disease course and prediction of long-term outcome remains a major challenge. Here, we investigate five myeloid markers – CHIT1, CHI3L1, sTREM2, GPNMB and CCL18 – in the cerebrospinal fluid (CSF) at diagnostic lumbar puncture in a longitudinal cohort of 192 MS patients. Through mixed-effe...
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CHIT1 at diagnosis predicts faster disability progression and reflects early microglial activation in multiple sclerosis
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TN_cdi_doaj_primary_oai_doaj_org_article_d13afc90e71e462b8aff607bbf1a03d9
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d13afc90e71e462b8aff607bbf1a03d9
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-49312-y
