Epigenetic activation of the FLT3 gene by ZNF384 fusion confers a therapeutic susceptibility in acut...
Epigenetic activation of the FLT3 gene by ZNF384 fusion confers a therapeutic susceptibility in acute lymphoblastic leukemia
About this item
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Author / Creator
Zhao, Xujie , Wang, Ping , Diedrich, Jonathan D. , Smart, Brandon , Reyes, Noemi , Yoshimura, Satoshi , Zhang, Jingliao , Yang, Wentao , Barnett, Kelly , Xu, Beisi , Li, Zhenhua , Huang, Xin , Yu, Jiyang , Crews, Kristine , Yeoh, Allen Eng Juh , Konopleva, Marina , Wei, Chia-Lin , Pui, Ching-Hon , Savic, Daniel and Yang, Jun J.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
FLT3
is an attractive therapeutic target in acute lymphoblastic leukemia (ALL) but the mechanism for its activation in this cancer is incompletely understood. Profiling global gene expression in large ALL cohorts, we identify over-expression of
FLT3
in
ZNF384
-rearranged ALL, consistently across cases harboring different fusion partn...
Alternative Titles
Full title
Epigenetic activation of the FLT3 gene by ZNF384 fusion confers a therapeutic susceptibility in acute lymphoblastic leukemia
Authors, Artists and Contributors
Author / Creator
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_d14b4f6c096c49f694347dc01d940e14
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d14b4f6c096c49f694347dc01d940e14
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-33143-w
