Spatio-temporal analysis of prostate tumors in situ suggests pre-existence of treatment-resistant cl...
Spatio-temporal analysis of prostate tumors in situ suggests pre-existence of treatment-resistant clones
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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The molecular mechanisms underlying lethal castration-resistant prostate cancer remain poorly understood, with intratumoral heterogeneity a likely contributing factor. To examine the temporal aspects of resistance, we analyze tumor heterogeneity in needle biopsies collected before and after treatment with androgen deprivation therapy. By doing so,...
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Full title
Spatio-temporal analysis of prostate tumors in situ suggests pre-existence of treatment-resistant clones
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TN_cdi_doaj_primary_oai_doaj_org_article_d1623c1686dc4be4860f28f2dd32be90
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d1623c1686dc4be4860f28f2dd32be90
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-33069-3
