KLHL25-ACLY module functions as a switch in the fate determination of the differentiation of iTreg/T...
KLHL25-ACLY module functions as a switch in the fate determination of the differentiation of iTreg/Th17
About this item
Full title
Author / Creator
Tian, Miaomiao , Hao, Fengqi , Jin, Xin , Wang, Xinyu , Chang, Tianyi , He, Shuang , Wang, Huiyue , Jiang, Ying , Wang, Yang , Liu, Jia , Feng, Yunpeng , Li, Dan , Yin, Zhinan , Ba, Xueqing and Wei, Min
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The differentiation of Th17 and iTreg is tightly associated with fatty acid metabolism. TGFβ1-induced iTreg differentiation from Th0 relies on fatty acid oxidation (FAO), whereas IL-6 with TGFβ1 shifts metabolism to Th17-preferred fatty acid synthesis (FAS). However, how IL-6 reprograms fatty acid metabolism remains unclear. Here, we unveiled that...
Alternative Titles
Full title
KLHL25-ACLY module functions as a switch in the fate determination of the differentiation of iTreg/Th17
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_d1c2c0a0be214c01887124d01e837b04
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d1c2c0a0be214c01887124d01e837b04
Other Identifiers
ISSN
2399-3642
E-ISSN
2399-3642
DOI
10.1038/s42003-025-07917-z
