Translational Model‐Informed Dose Selection for a Human Positron Emission Tomography Imaging Study o...
Translational Model‐Informed Dose Selection for a Human Positron Emission Tomography Imaging Study of JNJ‐54175446, a P2X7 Receptor Antagonist
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United States: John Wiley & Sons, Inc
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English
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United States: John Wiley & Sons, Inc
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Positron emission tomography (PET) provides useful information in target engagement or receptor occupancy in the brain for central nervous system (CNS) drug development, however, dose selection for human PET studies is challenging and largely empirical. Here, we describe a translational pharmacokinetic/pharmacodynamic (PK/PD) modeling work to infor...
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Translational Model‐Informed Dose Selection for a Human Positron Emission Tomography Imaging Study of JNJ‐54175446, a P2X7 Receptor Antagonist
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TN_cdi_doaj_primary_oai_doaj_org_article_d20afbe76b7844baaac6ee5ea1578e10
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d20afbe76b7844baaac6ee5ea1578e10
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ISSN
1752-8054
E-ISSN
1752-8062
DOI
10.1111/cts.12711
