Discovery of driver non-coding splice-site-creating mutations in cancer
Discovery of driver non-coding splice-site-creating mutations in cancer
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Non-coding mutations can create splice sites, however the true extent of how such somatic non-coding mutations affect RNA splicing are largely unexplored. Here we use the MiSplice pipeline to analyze 783 cancer cases with WGS data and 9494 cases with WES data, discovering 562 non-coding mutations that lead to splicing alterations. Notably, most of...
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Full title
Discovery of driver non-coding splice-site-creating mutations in cancer
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TN_cdi_doaj_primary_oai_doaj_org_article_d2a72161fdd34e848ad4dc5d066b00b8
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d2a72161fdd34e848ad4dc5d066b00b8
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-19307-6
