A synaptic F-actin network controls otoferlin-dependent exocytosis in auditory inner hair cells
A synaptic F-actin network controls otoferlin-dependent exocytosis in auditory inner hair cells
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England: eLife Science Publications, Ltd
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English
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England: eLife Science Publications, Ltd
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We show that a cage-shaped F-actin network is essential for maintaining a tight spatial organization of Cav1.3 Ca(2+) channels at the synaptic ribbons of auditory inner hair cells. This F-actin network is also found to provide mechanosensitivity to the Cav1.3 channels when varying intracellular hydrostatic pressure. Furthermore, this F-actin mesh n...
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Full title
A synaptic F-actin network controls otoferlin-dependent exocytosis in auditory inner hair cells
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TN_cdi_doaj_primary_oai_doaj_org_article_d2dc8032c0814d8796d5539d1a3a64aa
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d2dc8032c0814d8796d5539d1a3a64aa
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.10988
