Astrocytic lactate dehydrogenase A regulates neuronal excitability and depressive-like behaviors thr...
Astrocytic lactate dehydrogenase A regulates neuronal excitability and depressive-like behaviors through lactate homeostasis in mice
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Alterations in energy metabolism are associated with depression. However, the role of glycolysis in the pathogenesis of depression and the underlying molecular mechanisms remain unexplored. Through an unbiased proteomic screen coupled with biochemical verifications, we show that the levels of glycolysis and lactate dehydrogenase A (LDHA), a glycoly...
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Astrocytic lactate dehydrogenase A regulates neuronal excitability and depressive-like behaviors through lactate homeostasis in mice
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TN_cdi_doaj_primary_oai_doaj_org_article_d2df2840bdd647cd8bb7bb8ce72c67aa
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d2df2840bdd647cd8bb7bb8ce72c67aa
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-36209-5
