The novel BET‐CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild‐type prostate cancer
The novel BET‐CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild‐type prostate cancer
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Author / Creator
Yan, Yuqian , Ma, Jian , Wang, Dejie , Lin, Dong , Pang, Xiaodong , Wang, Shangqian , Zhao, Yu , Shi, Lei , Xue, Hui , Pan, Yunqian , Zhang, Jun , Wahlestedt, Claes , Giles, Francis J , Chen, Yu , Gleave, Martin E , Collins, Collin C , Ye, Dingwei , Wang, Yuzhuo and Huang, Haojie
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
CULLIN3‐based E3 ubiquitin ligase substrate‐binding adaptor gene
SPOP
is frequently mutated in prostate cancer (PCa). PCa harboring SPOP hotspot mutants (e.g., F133V) are resistant to BET inhibitors because of aberrant elevation of BET proteins. Here, we identified a previously unrecognized mutation Q165P at the edge of SPOP MATH domain in pr...
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Full title
The novel BET‐CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild‐type prostate cancer
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TN_cdi_doaj_primary_oai_doaj_org_article_d2f7b0ca67d14b41bbeaa424e6975672
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d2f7b0ca67d14b41bbeaa424e6975672
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ISSN
1757-4676
E-ISSN
1757-4684
DOI
10.15252/emmm.201910659
