A feed forward loop enforces YAP/TAZ signaling during tumorigenesis
A feed forward loop enforces YAP/TAZ signaling during tumorigenesis
About this item
Full title
Author / Creator
Gill, Mandeep K. , Christova, Tania , Zhang, Ying Y. , Gregorieff, Alex , Zhang, Liang , Narimatsu, Masahiro , Song, Siyuan , Xiong, Shawn , Couzens, Amber L. , Tong, Jiefei , Krieger, Jonathan R. , Moran, Michael F. , Zlotta, Alexandre R. , van der Kwast, Theodorus H. , Gingras, Anne-Claude , Sicheri, Frank , Wrana, Jeffrey L. and Attisano, Liliana
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
In most solid tumors, the Hippo pathway is inactivated through poorly understood mechanisms that result in the activation of the transcriptional regulators, YAP and TAZ. Here, we identify NUAK2 as a YAP/TAZ activator that directly inhibits LATS-mediated phosphorylation of YAP/TAZ and show that NUAK2 induction by YAP/TAZ and AP-1 is required for rob...
Alternative Titles
Full title
A feed forward loop enforces YAP/TAZ signaling during tumorigenesis
Authors, Artists and Contributors
Author / Creator
Christova, Tania
Zhang, Ying Y.
Gregorieff, Alex
Zhang, Liang
Narimatsu, Masahiro
Song, Siyuan
Xiong, Shawn
Couzens, Amber L.
Tong, Jiefei
Krieger, Jonathan R.
Moran, Michael F.
Zlotta, Alexandre R.
van der Kwast, Theodorus H.
Gingras, Anne-Claude
Sicheri, Frank
Wrana, Jeffrey L.
Attisano, Liliana
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_d30df4cc14bf4f8f98f52cdb55527dcc
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d30df4cc14bf4f8f98f52cdb55527dcc
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-05939-2
